Toward personalized synchrotron microbeam radiation therapy
نویسندگان
چکیده
منابع مشابه
New prospects for brain tumour radiotherapy: Synchrotron light and Microbeam Radiation Therapy Microbeam radiation therapy (MRT): Milestones - Clinical prospects
J.A. Laissue , H. Blattmann 1 , M.A. Grotzer 2 , B. Kaser-Hotz , D.N. Slatkin , H.P. Wagner 5 1 Institut für Pathologie, Universität Bern, CH-3010 Bern, Switzerland 2 Universitäts-Kinderkliniken, CH-8032 Zürich, Switzerland 3 Vetsuisse Fakultät, Universität Zürich, CH-8057 Zürich, Switzerland 4 Brookhaven National Laboratory, Upton, New York 11973-5000, USA 5 Universitäts-Kinderkliniken des Ins...
متن کاملMicrobeam radiation therapy.
It is proposed to carry out radiotherapy and radiosurgery for brain lesions by crossfiring an array of parallel, closely spaced microbeams of synchrotron-generated x rays several times through an isocentric target, each microbeam in the array having an approximately 25-microns-wide adjustable-height rectangular cross section. The following inferences from the known tissue sparing of 22-MeV deut...
متن کاملMedical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT).
Stereotactic Synchrotron Radiotherapy (SSRT) and Microbeam Radiation Therapy (MRT) are both novel approaches to treat brain tumor and potentially other tumors using synchrotron radiation. Although the techniques differ by their principles, SSRT and MRT share certain common aspects with the possibility of combining their advantages in the future. For MRT, the technique uses highly collimated, qu...
متن کاملMOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility.
Preclinical experiments are carried out with approximately 20-30 microm wide, approximately 10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (approximately 50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate and/or unsafe. Novel physical microdosimetry (implemented with MOSFET chips in t...
متن کاملPreferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks.
PURPOSE Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of the incident photon beam into parallel micron-wide beams. Our aim was to analyze the effects of MRT on normal brain and 9L gliosarcoma tissues, particularly on blood vessels. METHODS AND MATERIALS Responses to MRT (two arrays, one lateral, one anteroposterior (2 × 400 Gy), intersecting orthogonally in the...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-65729-z